Azadirachta indica (Neem), an herb extensively used in Ayurveda to treat many health related problems and ailments, and also known to exert anticancer, antioxidant, wound-healing, and antimicrobial properties is also known to be one of these plants from which almost every part is used, from the Neem oil extracted from its seeds to the leaves and branches. As in other herbs, Neem beneficial effects are given by some of its active constituents, some of which the pharmaceutical industry have used as their primary source to build drugs against illnesses as important as cancer, for which already more than 400 active constituents derived from plants and herbs are used. Herbs as Neem and Ginkgo biloba as well as many other well renown herbs, have been in the scope of pharmaceutical companies since long ago, mainly due to the properties and health benefits exerted by some of their active constituents known to act as health boosters. Azadirachta indica (Neem) however has a main target on which its use seems to be highly effective, skin and skin related problems, either as part of poly herbal anti-acne face wash gels formulations, or part of antimicrobial preparations against some groups of bacteria as Escherichia coli. Five active constituents found in Azadirachta indica showed an important inhibitory effect on the melanogenesis in the melanoma cells, with which Neem becomes one of these plants to be noted for the development of new drugs based on the active constituents of this plant.